Table 3.

GO cellular components and complexes for all phenotype categories. Summary of the GO analysis for cellular components enriched within particular phenotype categories. For details see §5.5.2 and electronic supplementary material 1, tables S7a–n and S14. For further details, see table 2 legend. Footnotes are denoted by a–u. Red colour denotes enriched p ≤ 0.001; orange denotes moderately enriched p ≤ 0.01; light orange denotes weakly enriched p ≤ 0.1; light blue denotes no enrichment p ≤ 1; blank denotes number of genes is 0.

Embedded Image
  • aIncludes164/193 genes annotated to plasma membrane (p = 1.74 × 10−9) and 661/914 genes annotated to intrinsic to membrane (p = 5.45 × 10−9), both descendents of membrane.

  • bIncludes 7/8 subunits of chaperonin containing T-complex (p = 1. 29 × 10−7) and 4/5 subunits of eukaryotic translation initiation factor 2B complex (p = 0.001).

  • cIncludes 5/8 subunits of COP I coated vesicle membrane (p = 0.001).

  • dIncludes 8/14 subunits of vacuolar proton-transporting V-type ATPase complex (p = 7.26 × 10−6).

  • eSee table 4 for breakdown of nuclear complexes.

  • fIncludes 5/8 subunits of Arp2/3 protein complex (p = 0.00922).

  • gIncludes 5/7 subunits of oligosaccharyltransferase complex (p = 0.003), 3/3 subunits of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) (p = 0.05068), 6/11 subunits of TRAPP complex (p = 0.00417) and 4/4 subunits GARP complex (p = 0.00313).

  • hIncludes 2/4 subunits of AP-1 adaptor complex (p = 0.02077).

  • iIncludes 12/81 genes annotated to cytosolic large ribosomal subunit (p = 0.00936), a descendent of ribosome.

  • jIncludes 5/6 subunits of elongator holoenzyme complex (p = 0.002) and 5/5 subunits of RNA cap binding complex (p = 0.0004).

  • kIncludes 32/211 genes annotated to spindle pole body (p = 0.006), a descendent of microtubule cytoskeleton.

  • lIncludes 20/211 genes annotated to spindle pole body (p = 0.00014), a descendent of microtubule cytoskeleton.

  • mIncludes 2/4 subunits of mitochondrial sorting and assembly machinery complex (p = 0.22496).

  • nIncludes 2/2 subunits of eRF1 methyltransferase complex (p = 0.03840).

  • oIncludes 4/8 subunits of mannosyltransferase complex (p = 0.00081).

  • pIncludes 8/194 genes annotated to ER membrane (p = 0.15), a descendent of Golgi/ER.

  • qIncludes 4/10 genes annotated to equatorial MTOC (p = 0.00015) and 8/51 genes annotated to spindle pole body (p = 0.1), descendents of microtubule cytoskeleton.

  • rIncludes 2/2 subunits of tea1 cell end complex (p = 0.008).

  • sIncludes 4/211 genes annotated to spindle pole body (p = 1), a descendent of microtubule cytoskeleton.

  • tAll 61 genes encode subunits of mitochondrial ribosome (61/70 subunits p = 3.98 × 10−88).

  • uIncludes 20/173 genes annotated to mitochondrial membrane (p = 6.38 × 10−6), a descendent of membrane.