Table 1.

Identified roles for intra-axonal mRNA translation.

function of local translationassociated transcript(s)
chemotropic response to guidance cuesRhoA [11], β-actin [1214], cofilin [15]
axon elongationPAR-3 [16], β-thymosin [17], ATP5G1 [18], COXIV [19], ALCAM [20]
axon branchingβ-catenin [21]
axon maintenanceIMPA1 [22], Lamin β [23], ATP5G1 [18], COXIV [24], Cpg15 [25]
axon/neurite regenerationRPL4 [26], Importin β [27,28], RanBP1 [28], Vimentin [29], NF-L, NF-M, NF-H [30]
retrograde signalling: neuronal survivalCREB [31], STAT3 [32]
retrograde signalling: tissue patterningSmad 1/5/8 [33]
synapse formationCEBP-1 [34], α-tubulin [35], Sensorin [36]
unknown functionOdorant receptors [37], KOR1 [38]